ABSTRACT
Objective To study the effect on proliferation of glomerular mesangial(GMC) cell by the dose compatible proportion between Radix Astrsgali and Radix Notoginseng in Tongmai Oral Liquid(TMOL) so as to select the optimal dose proportion.Methods We used serological pharmacological methods to prepare Decoction of Tongmai of different dose proportions and assay its effect on the proliferation of GMC to confirm the best dose compatible proportion between Radix Astrsgali and Radix Notoginseng of Decoction of Tongmai.Results Both TMOL and the different proportions between Radix Astrsgali and Radix Notoginseng(6∶1,3∶1,1.5∶1) of Decoction of Tongmai could inhibit the proliferation of GMC cultured either in fetal cow serum(FCS) or in FCS plus lipoplysaccharide.The inhibitory effect of Decoction of Tongmai(3∶1) group was better than both Decoction of Tongmai 6∶1 and Decoction of Tongmai 1.5∶1.Conclusion The dose compatible proportion between Radix Astrsgali and Radix Notoginseng in TMOL was reasonable.